The overall objective of this program project is to explore and improve the utilization of radiation and combinations of radiation and other modalities in order to increase the cancer cure rate and to evaluate the long-term effects of radiation and combinations of radiation and other modalities; thus, not only to increase the cure rate but preserve function and cosmesis in the cancer patient. These objectives will be achieved by: a. Continuing the development of a specialized Radiation-Oncology Research and Clinical Center. This Center will continue to develop an overall integrated program for research in radiation biology, radiation immunology, radiation physics and related basic sciences and continue to promote, enhance and stimulate the investigation of the basic mechanisms of radiation and combinations of radiation and other agents in the treatment and control of cancer and evaluation of long-term effect with the goal of possible human application. b. Continuing to expand our overall integrated program to carry out clinical research utilizing radiation combined with other agents to improve results of the treatment of human cancer and to integrate information obtained from basic research whenever possible into the clinical treatment. c. Continuing to provide a center for demonstration and teaching of the appropriate advanced therapeutic methods and techniques so that these can be taught to physicians, medical students, and support personnel of this area and thus be made available to patients. d. Continuing to provide and further develop our Training Program in radiation oncology for graduate and undergraduate physicians, technicians, and nurses for this region. e. Continuing our development of the Outreach Program to improve radiation therapy and subsequently all methods of cancer treatment in the outlying communities of the region.